antiSMASH¶
The antibiotics and Secondary Metabolites Analysis SHell antiSMASH is a fully automated pipeline to mine bacterial and fungal genome date for secondary metabolite biosynthetic gene clusters (BGCs). The small molecules encoded by these BGCs often have various bioactivities including antimicrobial, anti-cancer, anthelminthic and others. Therefore they are lead compounds for many drugs like antibiotics.
antiSMASH was initially developed in a collaborative project between Tübingen University (Tilmann Weber, Kai Blin), Groningen University (Eriko Takano, Rainer Breitling, Marnix Medema) and UCSF (Michael Fischbach). Currently, antiSMASH development is coordinated at Wageningen University and the Novo Nordisk Foundation Center for Biosustainability / Technical University of Denmark
Link to antiSMASH server¶
http://antismash.secondarymetabolites.org
antiSMASH download¶
http://antismash.secondarymetabolites.org/download.html
antiSMASH online documentation¶
http://docs.antismash.secondarymetabolites.org
antiSMASH source code repository¶
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websmash source code for web component of antiSMASH web server
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dispatcher source code for job scheduling component of antiSMASH web server
References¶
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Blin, K., et al., 2017, Nucleic Acids Res. doi: 10.1093/nar/gkx319
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Medema, M. H., et al., 2011, Nucleic Acids Res. 39: W339-W346
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Leclère, V., et al., 2016, Methods Mol Biol. 2016;1401:209-32
antiSMASH core developer team (alphabetic)¶
- Kai Blin
- Hyun Uk Kim
- Marnix Medema
- Simon Shaw
- Tilmann Weber
Contact¶
- Please use the Contact Form at the antiSMASH homepage.
Keywords:
genome mining, ClusterFinder, gene, genome, pathway, gene cluster, secondary metabolite