Tools to analyze PKS and NRPS megasynthase domain organization

Table of Contents

antiSMASH

please see antiSMASH page

ClustScan Professional

ClustScan Professional is a is a commercial Java-based tool to identify PKS and NRPS gene clusters in genomic data. A 30-days evaluation license is available.

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GNP/PRISM

please see GNP /PRISM in the Tools for cluster mining section

MAPSI/MAPSIdb/ASMPK

The MAPSI System can be used to identify PKS domain in the PKS megasynthase sequences.

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NaPDoS

The Natural Products Domain Seeker uses a phylogenetic approach to identify and classify Condensation domains of NRPS and KS domains of PKS enzymes.

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NP.searcher

NP.searcher is a tool to identify type I PKS, NRPS and mixed PKS/NRPS in genomic data and use the information on the identified catalytic domains to predict structures of the metabolites encoded by the BGCs

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PKS/NRPS Web Server/Predictive Blast Server

please see Specificity prediction for NRPS.

SEARCHPKS/NRPS-PKS/SBSPKS

SEARCHPKS was one of the first automated tools able to automatically identify the catalytic domains of PKS megasyntase enzymes. In 2004, SEARCHPKS was integrated in the more comprehensive NRPS-PKS / SBSPKS framework. For PKS, SBSPKS also contains function to generate homology model and docking interface analyses. NRPS-PKS also contains a database of representative PKS and NRPS pathways.

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