Tools to analyze PKS and NRPS megasynthase domain organization¶
please see antiSMASH page
ClustScan Professional is a is a commercial Java-based tool to identify PKS and NRPS gene clusters in genomic data. A 30-days evaluation license is available.
The MAPSI System can be used to identify PKS domain in the PKS megasynthase sequences.
- http://gate.smallsoft.co.kr:8008/pks/ (Currently not working - Server not found)
The Natural Products Domain Seeker uses a phylogenetic approach to identify and classify Condensation domains of NRPS and KS domains of PKS enzymes.
NP.searcher is a tool to identify type I PKS, NRPS and mixed PKS/NRPS in genomic data and use the information on the identified catalytic domains to predict structures of the metabolites encoded by the BGCs
PKS/NRPS Web Server/Predictive Blast Server¶
please see Specificity prediction for NRPS.
SEARCHPKS was one of the first automated tools able to automatically identify the catalytic domains of PKS megasyntase enzymes. In 2004, SEARCHPKS was integrated in the more comprehensive NRPS-PKS / SBSPKS framework. For PKS, SBSPKS also contains function to generate homology model and docking interface analyses. NRPS-PKS also contains a database of representative PKS and NRPS pathways.