The antibiotics and Secondary Metabolites Analysis SHell antiSMASH is a fully automated pipeline to mine bacterial and fungal genome date for secondary metabolite biosynthetic gene clusters (BGCs). The small molecules encoded by these BGCs often have various bioactivities including antimicrobial, anti-cancer, anthelminthic and others. Therefore they are lead compounds for many drugs like antibiotics.

antiSMASH was initially developed in a collaborative project between Tübingen University (Tilmann Weber, Kai Blin), Groningen University (Eriko Takano, Rainer Breitling, Marnix Medema) and UCSF (Michael Fischbach). Currently, antiSMASH development is coordinated at Wageningen University and the Novo Nordisk Foundation Center for Biosustainability / Technical University of Denmark

antiSMASH download

antiSMASH online documentation

antiSMASH source code repository


antiSMASH core developer team (alphabetic)

  • Kai Blin
  • Hyun Uk Kim
  • Marnix Medema
  • Simon Shaw
  • Tilmann Weber



genome mining, ClusterFinder, gene, genome, pathway, gene cluster, secondary metabolite